Can you donate blood if you are on testosterone therapy?
Testosterone can raise your hematocrit, so it is assessed case by case. Prescribed therapy is often acceptable if your levels are in range, while non-prescribed use is not.
Prescribed testosterone, whether for low testosterone or as gender-affirming hormone therapy, can affect values that matter for donation.
Why it matters
- Testosterone stimulates red blood cell production and can push hematocrit and hemoglobin above the allowed range
- Use without a prescription, or at very high doses, can affect blood quality and donor safety
Common situations
| Situation | What to expect |
|---|---|
| Prescribed testosterone, normal hematocrit | Often evaluated case by case and may be accepted |
| Gender-affirming hormone therapy | Evaluated individually; hematocrit is checked |
| Non-prescribed or performance use | Deferral |
| Stopping testosterone | Wait for values to normalize |
Hemoglobin and hematocrit
These are checked at screening. If your value is above the allowed limit on the day, you will be deferred for that visit.
Transgender donors
Policies differ between centers, and the FDA updated donor screening in 2023. Tell the screener about your hormone therapy so the right assessment is made.
Always list every hormone and medication you take.
Therapeutic phlebotomy for high red cell counts is a separate matter handled by your doctor.
This information is general and does not replace advice from a health professional. Your eligibility is always decided at the donor screening on the day of donation. Rules change, so confirm with the American Red Cross or the blood center where you plan to donate.